News RSF_en HondurasAmericas Organisation Follow the news on Honduras News April 27, 2021 Find out more Two journalists have reported receiving credible threats in early November although the Inter-American Commission on Human Rights (IACHR) had asked the Honduran authorities to provide them with protection.They are Arnulfo Aguilar, the head of Radio Uno, a radio station located in the northwestern city of San Pedro Sula, and Luis Galdamez, programme director at Tegucigalpa-based Radio Globo. Both are critics of the June 2009 coup and both have provided critical coverage of the activities of the armed forces and police.“The protective measures requested by the IACHR for persecuted journalists have long been a dead letter in the absence of real implementation by the authorities, who must end the ordeals of Aguilar and Galdamez by providing them and their news media with proper security.” Reporters Without Borders said. “Compliance with this requirement was one of the undertakings that the Honduran government gave in return for its readmission to the Organization of American States. It must be respected.”Aguilar, who narrowly escaped an armed ambush outside his home on 27 April, has notified the Committee of Families of Detainees and Disappeared in Honduras (COFADEH) that he received threats against himself and his daughter on his mobile phone. Aguilar has repeatedly been targeted by the security forces since the coup and one of his journalists, Medardo Flores, was murdered on 8 September.According to the Committee for Free Expression (C-Libre), a Reporters Without Borders partner organization, Galdamez was on the air, hosting his programme “Tras la Verdad” (Behind the Truth), when he received a threatening call from an individual who identified himself as a member of the armed forces. The caller said: “Come over here, we are waiting for you, as you spend your time ranting on about the police and army.”Galdamez has also been the victim of military violence since the coup. He was one of the journalists who were with deposed President Manuel Zelaya after his clandestine return to Honduras, when he sought refuge in the Brazilian embassy.In a separate development, Gabriel Álvarez Padget, the son of Televicentro journalist Renato Álvarez, was threatened by individuals who put a gun to his head as he left their Tegucigalpa home on 9 November. Renato Álvarez recently called for a purge of the police force after at least eight of its members were accused of involvement in the murder of two students. The murder investigation has ground to a halt because the police are not cooperating.“The government’s anti-crime drive, Operation Lightning is not going to solve the problems of violence and impunity,” Reporters Without Borders added. “There will be no progress on that front until the former and current commanders of the police and armed forces publicly account for the human rights violations since the coup and hand over all the documents needed to solve the 16 murders of journalists since 2010.”Operation Lightning has aroused a great deal of concern among community and grass roots movements, especially in the militarized Lower Aguán region where many human rights violations and extra-judicial executions have been reported. A survey of community radio broadcasting is urgently needed to satisfy the right to media diversity and the right of Honduran communities to their own radio stations, which are the target of attacks by landowners, often with the complicity of the armed forces. RSF’s 2020 Round-up: 50 journalists killed, two-thirds in countries “at peace” November 15, 2011 – Updated on January 20, 2016 No real protection for opposition journalists from threats blamed on military HondurasAmericas RSF begins research into mechanisms for protecting journalists in Latin America 2011-2020: A study of journalist murders in Latin America confirms the importance of strengthening protection policies Reports Receive email alerts to go further May 13, 2021 Find out more Help by sharing this information News December 28, 2020 Find out more
Background: Duplicated genes are common in vertebrate genomes. Their persistence is assumed to be either a consequence of gain of novel function (neofunctionalisation) or partitioning of the function of the ancestral molecule (sub-functionalisation). Surprisingly few studies have evaluated the extent of such modifications despite the numerous duplicated receptor and ligand genes identified in vertebrate genomes to date. In order to study the importance of function in the maintenance of duplicated genes, sea bream (Sparus auratus) PAC(1) receptors, sequence homologues of the mammalian receptor specific for PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide), were studied. These receptors belong to family 2 GPCRs and most of their members are duplicated in teleosts although the reason why both persist in the genome is unknown. Results: Duplicate sea bream PACAP receptor genes (sbPAC(1)A and sbPAC(1)B), members of family 2 GPCRs, were isolated and share 77% amino acid sequence identity. RT-PCR with specific primers for each gene revealed that they have a differential tissue distribution which overlaps with the distribution of the single mammalian receptor. Furthermore, in common with mammals, the teleost genes undergo alternative splicing and a PAC(1)Ahop1 isoform has been characterised. Duplicated orthologous receptors have also been identified in other teleost genomes and their distribution profile suggests that function may be species specific. Functional analysis of the paralogue sbPAC(1)s in Cos7 cells revealed that they are strongly stimulated in the presence of mammalian PACAP(27) and PACAP(38) and far less with VIP (Vasoactive Intestinal Peptide). The sbPAC(1) receptors are equally stimulated (LOG(EC50) values for maximal cAMP production) in the presence of PACAP27 (-8.74 +/- 0.29 M and -9.15 +/- 0.21 M, respectively for sbPAC(1)A and sbPAC(1)B, P > 0.05) and PACAP(38) (-8.54 +/- 0.18 M and -8.92 +/- 0.24 M, respectively for sbPAC(1)A and sbPAC(1)B, P > 0.05). Human VIP was found to stimulate sbPAC(1)A (-7.23 +/- 0.20 M) more strongly than sbPAC(1)B (-6.57 +/- 0.14 M, P < 0.05) and human secretin (SCT), which has not so far been identified in fish genomes, caused negligible stimulation of both receptors. Conclusion: The existence of functionally divergent duplicate sbPAC(1) receptors is in line with previously proposed theories about the origin and maintenance of duplicated genes. Sea bream PAC(1) duplicate receptors resemble the typical mammalian PAC(1), and PACAP peptides were found to be more effective than VIP in stimulating cAMP production, although sbPAC(1)A was more responsive for VIP than sbPAC(1)B. These results together with the highly divergent pattern of tissue distribution suggest that a process involving neofunctionalisation occurred after receptor duplication within the fish lineage and probably accounts for their persistence in the genome. The characterisation of further duplicated receptors and their ligands should provide insights into the evolution and function of novel protein-protein interactions associated with the vertebrate radiation.
After announcing their first scheduled dates of 2018 late last year, Seattle-native indie-folk outfit Fleet Foxes have announced several newly added shows along the tour. In addition to sets at high profile festivlass like Coachella, Shaky Knees and Boston Calling, the tour will take them to both coasts and virtually everywhere in between from early March through the end of May, followed by a Toronto date in July.Watch the new tour date announcement video posted to Fleet Foxes Facebook page earlier today:For further information about Fleet Foxes’ upcoming Spring 2018 tour, or to purchase tickets to any of the nearly 20 upcoming performances, head on over to the Fleet Foxes website today.Fleet Foxes Spring 2018 Tour Dates:^ – Denotes Newly Added Date03/01/18 – Tampa, FL @ The Ritz Ybor03/02/18 – St. Augustine, FL @ St. Augustine Amphitheatre03/03/18 – Orlando, FL @ House of Blues Orlando03/04/18 – Miami, FL @ The Fillmore at Jackie Gleason Theatre03/06/18 – North Charleston, SC @ North Charleston Performing Arts^03/07/18 Wed Charlotte, NC @ The Fillmore Charlotte03/09/18 – Jackson, MS @ Thalia Mara Hall03/10/18 – Memphis, TN @ Cannon Center for the Performing Arts03/11/18 – Mobile, AL @ Soul Kitchen03/12/18 – New Orleans, LA @ Orpheum Theatre^04/10/18 Tue Eugene, OR @ McDonald Theatre^04/11/18 Wed Sacramento, CA @ Crest Theatre^04/18/18 Wed San Luis Obispo, CA @ Madonna Expo Center^04/20/18 Fri Berkeley, CA @ Greek Theatre^05/03/18 Thu Raleigh, NC @ Red Hat Amphitheatre^05/07/18 Mon Houston, TX @ Revention Music Center^05/08/18 Tue San Antonio, TX @The Tobin Center for The Performing Arts^05/10/18 Thu El Paso, TX @ Abraham Chavez Theatre^05/12/18 Sat Albuquerque, NM @ Sunshine Theater^05/14/18 Mon Tulsa, OK @ Cain’s Ballroom^05/15/18 Tue St Louis, MO @ Peabody Opera House^05/17/18 Thu Pittsburgh, PA @ Benedum Center for the Performing Arts^05/18/18 Fri Washington, DC @ Anthem^05/19/18 Sat Columbus, OH @ Express Live05/21/18 Nashville, TN @ Ryman Auditorium^05/23/18 Wed Louisville, KY @ Iroquois Amphitheatre^05/24/18 Thu Indianapolis, IN @ The Murat Theatre^05/26/18 Sat South Burlington, VT @ The Green at The Shelburne Museum^07/24/18 Tue Toronto, ON @ Sony Centre for the Performing Arts[Cover photo via Kyle Johnson for the New York Times]
Press Association The visitors went close once again two minutes later when Ryan Bennett turned Pilkington’s deep free-kick towards goal to prompt a block by keeper Tim Krul, with returning skipper Fabricio Coloccini blocking Fer’s follow-up and Ameobi mopping up. However, with Cheick Tiote and Cabaye dominating in midfield and Ameobi and Remy stretching the Norwich defence, Newcastle gradually established a momentum. Moussa Sissoko should have extended their lead 14 minutes before the break after Ameobi had carved the City defence wide open with a slide-rule pass, but he dragged his effort wide. Norwich were very nearly level within seconds when Pilkington looped a header back across goal, only for the ball to drop just wide with Krul fatally wrong-footed. However, Pardew’s men increased their advantage with 38 minutes gone when Ameobi once again produced a fine pass to pick out Remy, who fed Sissoko to float in a teasing cross. Ameobi climbed highest to forced a save from Ruddy, but Gouffran was on hand to tap home the rebound. Ruddy had to dive to his left to beat away Ameobi’s piledriver in stoppage time, and the home side headed for the dressing room happy with their lot. The visitors’ woes increased within four minutes of the restart when Pilkington was carried off after apparently damaging a hamstring in a challenge with Mapou Yanga-Mbiwa. Johan Elmander took his place, but it was Gary Hooper who might have changed his side’s fortunes from the resulting free-kick when Newcastle failed to clear their lines and he prodded a shot just wide. Ameobi created a shooting chance for himself with some neat footwork, but then wasted all the good work by scuffing his attempt straight at Ruddy. But Norwich were making a concerted push to get themselves back into the game and the Magpies found themselves having to defend, if with few scares, for an extended period. Newcastle were content to try to hit the Canaries on the break, which they did to good effect on more than one occasion, but the precision of their first-half performance was sadly lacking. The relative comfort of their position persuaded Pardew to withdraw the tiring Cabaye and Ameobi and replace them with Vurnon Anita and Papiss Cisse as time ran down. However, Fer set up a tense conclusion when he headed Redmond’s corner firmly past Krul with 10 minutes remaining, although the Magpies held firm. Loic Remy’s eighth goal of the season set Newcastle on the road to a third successive Barclays Premier League victory as Norwich’s troubles on the road continued. Norwich, who lost 7-0 at Manchester City in their last game, had first-half chances of their own with Anthony Pilkington, who was later carried off on a stretcher, sending a 32nd-minute header across the face of goal. However, Alan Pardew’s side were deserved winners on a day when they played well enough to take the points, but did not have to be at their very best in front of an appreciative crowd of 51,328. There were impressive individual displays from Cabaye and Remy, who helped France book their place at next summer’s World Cup finals in midweek, and Shola Ameobi, who will hope to join them in Brazil with Nigeria. The mood within the camp was understandably buoyant as a result of those international successes and morale-boosting victories over Chelsea and Tottenham, and Newcastle’s afternoon could hardly have got off to a better start. Less than two minutes had gone when Cabaye, for the second time in the game, sent in a left-wing corner which was allowed to travel across Norwich’s six-yard box to the far post. Midfielder Bradley Johnson found himself caught in two minds and in the event did nothing to allow Remy to head into the back of the net. The Canaries responded to the early set-back to enjoy their best, albeit brief, spell of the half. Nathan Redmond perhaps should have done better after being played in over the top by Michael Turner with 11 minutes gone, but he blasted high over with the Magpies’ defence waiting in vain for an offside flag. The France international headed home Yohan Cabaye’s corner from close range with just two minutes gone, remarkably the Magpies’ first strike from that particular set-piece since October 2011. Compatriot Yoan Gouffran wrapped up the win seven minutes before the break, converting from close range after keeper John Ruddy had saved Shola Ameobi’s header, and Leroy Fer’s 80th-minute header ultimately counted for little in the 2-1 result despite sparking a rousing fightback.
Calling it her “one-year birthday wish,” ABC’s “Good Morning America” anchor Robin Roberts is asking people to join the Be The Match Registry® in celebration of the life-saving bone marrow transplant she received last September.This appeal for registry members, captured in a new public service announcement (PSA), is Roberts’ latest effort to raise awareness about Be The Match®, the nonprofit organization dedicated to helping patients with blood cancers like leukemia receive life-saving bone marrow and umbilical cord blood transplants.The new PSA premiered on “GMA” on Sept. 20. It builds on a series of PSAs, outdoor advertisements and more that Roberts has embarked on since partnering with Be The Match in 2012.Roberts began her crusade to recruit bone marrow donors shortly following her announcement on national television that she was battling myelodysplastic syndrome (MDS) and would need a bone marrow transplant to survive. Though her sister Sally-Ann was a perfect match, Roberts has worked tirelessly to raise awareness, hoping that other patients may find their perfectly matched donors.These efforts have ignited an incredible, and unprecedented, outpouring of support for Be The Match, with tens of thousands of people joining the registry as potential bone marrow donors. To recognize Roberts for all that she has done to help blood cancer patients everywhere, Be The Match recently honored Roberts with its Rod Carew Leadership Award—an award reserved for individuals who have made a profound difference in the lives of patients and their families through their leadership and commitment to Be The Match’s mission.Be The Match Honors ABC’s Robin Roberts with its Rod Carew Leadership AwardCredit/Copyright: PRNewsFoto/Be The Match“I was fortunate to receive a life-saving bone marrow transplant from my sister. But when I learned about the great need for bone marrow donors, especially in the African American community, I knew there was an important message to spread,” Roberts said in accepting the award via video on Sept. 21, during the sixth annual Be The Match Tribute fundraising event in Minneapolis. “I’ve been humbled by those people who’ve gone on to donate after hearing about my experiences, and it’s an honor to receive an award that bears Rod’s name and legacy.”Rod Carew, the baseball Hall-of-Famer, has been a leading advocate for a diverse donor registry since losing his daughter, Michelle, to leukemia in 1996. No one in Michelle’s family could provide a match, and their many efforts to find a suitable unrelated donor were unsuccessful.“Robin is a symbol of leadership and courage. She overcame incredible obstacles and continues to advocate on behalf of blood cancer patients,” said Jeffrey W. Chell, M.D., chief executive officer of Be The Match. “We are grateful for her support, amazed by her grace and honored to present her with the Rod Carew Leadership Award.”Robin Roberts’ Prayer For Protection wristbands at ShopBeTheMatch.org and Sephora – Time Square.Credit/Copyright: PRNewsFoto/Be The MatchIn addition to Robert’s awareness efforts, more than 325,000 “Robin Roberts’ Prayer for Protection” wristbands—designed by Roberts’ friends—have been sold to-date. One hundred percent of the net proceeds support the Be The Match mission to save lives through bone marrow transplants. The wristbands are available for purchase in packs of five for $5 at ShopBeTheMatch.org and two Time Square Sephora locations in New York City. Starting in mid-October, the wristbands also will be available for purchase online on the “Good Morning America” page at the official ABC TV Fan Store.About Be The MatchFor people with life-threatening blood cancers—like leukemia and lymphoma—or other diseases, a cure exists. Be The Match connects patients with their donor match for a life-saving marrow or umbilical cord blood transplant. People can contribute to the cure as a member of the Be The Match Registry, financial contributor or volunteer. Be The Match provides patients and their families one-on-one support, education, and guidance before, during and after transplant.Be The Match is operated by the National Marrow Donor Program® (NMDP), a nonprofit organization that matches patients with donors, educates health care professionals and conducts research so more lives can be saved. To learn more about the cure, visit BeTheMatch.org or call 1 (800) MARROW-2.Source:PR Newswire