(CLICK HERE, if you are unable to view this photo gallery on your mobile device.)The San Jose Sharks advanced to the Western Conference final after defeating the the Colorado Avalanche in Game 7.The team captain Joe Pavelski who has been out since a hit in Game 7 of the previous series returned to the ice. He immediately made an impact scoring the first goal of the game. He ended up with a score and an assist in his return.Pavelski celebrated two other times with teammates as Tomas Hertl …
Tags:#news#web The e-book hype reached its apex just before the holiday season. Now seems like a good time to take a closer look at the e-book market, especially given that this business is heading for another disruption once Apple’s iPad launches. According to the latest stats from the Book Industry Study Group (BISG), e-book usage is growing fast, but continues to represent a very small part of the publishing industry’s bottom line. Currently, only about 2% of American book buyers over 13 are active e-book users.E-Books Today: PCs, Kindles & iPhonesWhile 2% is still a very small number, the BISG (which represents numerous large publishing houses) found that e-book usage increased about 25% over the holiday season. Most people still read e-books on their PCs (47%), followed by the Kindle (32%) and the iPhone and iPod Touch (21%). As Michael Mace notes, it’s important to remember that this doesn’t take into account how many e-books these users actually bought. Chances are that Kindle users buy a lot more e-books than those who read e-books on their PCs.According to the BISG, a slight majority of e-book buyers is men (51% compared to 42% for paper books) and, unsurprisingly, these buyers have a higher than average income.How Many Kindles has Amazon Sold?Amazon, sadly, doesn’t give us any hard data about how many Kindles and e-books it has actually sold so far, which makes it rather hard to pinpoint any exact numbers for e-book usage. Based on the BISG’s data, Mace extrapolates that there are currently about 200 million active book buyers in the U.S. – which would mean that Amazon has sold roughly 1.3 million Kindles. What About the iPad?While a lot of (digital) ink has been spilled about Apple’s (and the publishing industry’s) pricing structure for e-books on the iPad, the far more interesting question is how publishers will use the iPad (and similar devices) to adapt their content for this new environment. While traditional e-book readers like the Kindle are great at recreating a book-like reading experience, the iPad, with its color screen and fast processor will be able to do a lot more – and readers will expect iPad e-books to be more interactive because of this. Earlier today, Penguin showed off some of the e-books it plans for the iPad (including DK’s guide to the human body and various travel guides). We can only hope that more publishers will follow Penguin’s lead. We already know that a lot of magazine publishers are planning to launch their own native iPad apps.It’s interesting to see that Apple’s iPhone and iPod touch are already the Kindle’s closest competitors. As Mace notes, iPhone users are probably less active e-book buyers than Kindle users, but Apple has clearly managed to capture a lot of the e-book mindshare thanks to the third-party e-book apps that are currently available for the iPhone and iPod touch.mindshare thanks to the third-party e-book apps that are currently available for the iPhone and iPod touch. Related Posts Top Reasons to Go With Managed WordPress Hosting frederic lardinois Why Tech Companies Need Simpler Terms of Servic… A Web Developer’s New Best Friend is the AI Wai… 8 Best WordPress Hosting Solutions on the Market
Follow @dfriend on Twitter. David Friend, The Canadian Press New Democrat legislators are calling on the Liberal government to reconsider a decision that denies funding to the National Arts Centre’s Indigenous Theatre.Five NDP members of parliament signed a letter on Friday to Heritage Minister Pablo Rodriguez urging a commitment to stable funding for the Indigenous theatre project, which launches its inaugural season this year.The letter says while the federal government has pledged to protect and promote Indigenous cultures and history, it “must go much further” and that includes acknowledging Indigenous cultures “as a foundational pillar of Canadian culture.”Playwright Kevin Loring, the first-ever artistic director of the NAC’s Indigenous program, posted a note on Facebook earlier this month lamenting a lack of support for the project from Canadian Heritage in the 2019 federal budget.He said it will have a tangible impact on the first season, leaving the Ottawa-based performing arts centre to rely on fundraising efforts. The scope of any subsequent seasons remains in question.The NDP MPs say the new theatre was created as a space for Indigenous people to share their stories “in the heart of our country’s capital for all to see and hear.”“Support for such a vision is key to reconciliation,” the letter added.New Democrat MP Niki Ashton asked the Liberals during question period on Monday why the government isn’t supporting the theatre program. Gary Anandasangaree, parliamentary secretary to Heritage Minister Rodriguez, responded saying the Liberals are working on reconciliation efforts. The first season’s lineup of NAC’s Indigenous Theatre is scheduled to be announced on April 30.
Recently, the other old hand in this new biochemistry, Craig Venter, asked Church during an interview if everything would still be copacetic—in other words, if mirror drugs and enzymes would really perform the exact same way in the mirror world. While drug companies may be salivating after Church’s short-latency positive answer, there is some intriguing evidence that more subtle symmetry-breaking electron spin effects could be at play. In one such conception, electrons originally in heterogenous spin states are released from an enzyme (like NADH synthase) and are subsequently filtered and polarized as they pass through chiral α-helix structures to the site of amino acid synthesis at the other end. This effectively produces “spin up” electrons that, if you can excuse the jargon, participate in the reductive reaction between α-oxo acid and ammonia with only L-amino acids forming according to the Pauli exclusion principle. In any event, to look in the mirror on the wall and see a biology that does not behave exactly like ours would seem to require some significant new parity breakdown in physics, to say the least.Now, olfaction is probably the space where these deuterium switches and chiral switches most informatively converge to elucidate how receptors might operate. In fact, the authors explicitly highlight the fact that their histamine receptor model may have something to say about olfactory receptors. Importantly, both of these receptor classes belong to the so-called GPCR (G-protein coupled receptor) family that vertebrates use to detect odorants; half of our own 800 GPCRs are provisioned almost exclusively to olfaction.The author’s main comments, here, center on the aromatic groups of molecules, features that are typically associated with delocalized electrons. For example, the imidazole ring of histidine (histamine’s the amino acid precursor) is aromatic at all pH values; four of its pi electrons form two double bonds and two from a nitrogen lone pair. The authors propose that a major fallout of deuteration is that the aromatic moiety shrinks the effective C–D distance relative to its C–H value. Aromatic C–H bonds act as proton donors and form weak hydrogen bonds with water molecules and proton acceptors at the receptor binding site. In other words, that deuterated odorants would be a little different from nondeuterated odorants—something that has actually been appreciated for some time. These comments are pointed straight at recent experiments by Luca Turin, who has advanced the theory of molecular vibration sensing in olfaction in which the nose performs an analysis akin to your favorite benchtop device. Depending on the interpretation, that instrument might be part mass spectrometer, part IR spectrometer, and part scanning tunneling microscope. In particular, they question the conclusion of Luca’s group that flies conditioned with progressively deuterated acetophenone could readily distinguished between the deuterated and nondeuterated varieties.In response, Luca quickly noted a few problems. For one, he fairly observes, ‘then how come the flies transfer learning from one deuterated compound to another, and from C-D stretch to C≡N ? By their lights, there should only be a difference in affinity. Why is there a commonality in smell character?’Perhaps more pointedly, he notes that there are no aromatic CH groups in his deturerated musk experiments, only aliphatic groups—something the authors wisely avoid citing. Furthermore, the authors don’t mention other work that shows very good correlations between vibrational spectra and agonist activity in histamine receptors.In a recent popular article, Luca has made a beginning toward a theory that puts the odor character back into the molecule. While not necessarily drugs, odors can be considered a special class of molecules with a much restricted receptor requirement. Due to inherent limitations in detecting volatiles, olfactory receptors can only expect to see molecules reflecting some trade-off in general stickiness and solubility—a compromise that makes specificity the frequent casualty. Luca proposed that GPCRs and their activators may be thought of as more like electronic components than the mechanical devices of the shape-based receptor paradigm. He suggests that cells could offer them in three styles—vibration (V), tunneling (T), and redox (R):Type V receptors tunnel electrons across a gap that corresponds to an energy jump by binding a molecule that possesses one or more vibrations at the correct energy. Type T have the same circuit topology, but without an energy jump. The receptor is turned on when a molecule binds to it and includes a feature, such as a positive charge, that lowers the barrier to electron tunneling. Finally, type r receptors only have the output half of the circuit where the ligand brings in the electron, and then undergoes an oxidation step when bound. Notably, GPCRs are frequently considered to be a predominantly Eukaryotic innovation. There is certainly evidence for GPCR precursors among the domains and motifs of proteins in lower life forms. However, bacteria generally go for more direct-acting receptors with efficient built-in ion channels as opposed to the laggy and protracted toggling of separate downstream ion channels actuated by messy G-protein cascades. For example, both bacteriorhodopsin and our rhodopsin belong to the ‘seven transmembrane domain’ family of proteins, but while rhodopsin is a GPCR, the ancient light-powered bacterial ion pump is probably not.Why is this the case? If the primary job of sensory neurons is simply to encode incoming information into spikes, then what could be better than speedy ligand gated ion channels? One hint is the observation that if mitochondria generated or otherwise quickly fell out of the advent of eukaryotism, and GPCRs were an integral part of that transition, then the expected intracellular effect from GPCRs might be direct control of the locally resident mitochondria. As possible counterpoint, here, one might point to those rare birds, the infinitesimal fairy flies that inexplicably jettison away much of their own neuronal nuclei and mitochondria and basically run on fumes till they expire. Such creatures might still sense and smell, but how well do they really do it? Explore further Citation: Using the ‘deuterium switch’ to understand how receptors work (2016, June 7) retrieved 18 August 2019 from https://phys.org/news/2016-06-deuterium-receptors.html The authors measured changes in the binding affinities of histamine receptor ligands after they replaced the normal buffer solution with D20 (deuterium oxide). In contrast to other kinds of studies in which the ligands themselves had deuterium permanently bound to carbon atoms, a heavy water solution would deuterate the ligand at exchangeable N-H and O-H protons. This trick directly targets the hydrogen bonds that presumably control ligand-receptor interactions and associated ligand-water interactions.There is no shortage of ways in which an extra neutron perturbs the life of a molecule. A two-fold mass gain decreases bond length and increases bond strength. This ultimately changes a number of physical and chemical properties, including molar volume, polarity, electron donation, Van der Waal’s forces, dipolar moment, and lipophilicity. For example, deuterated caffeine is known to elute faster in the lab on a gas chromatograph mass spectrometer. One might even imagine trying to capture nature’s most elusive superbuzz by drinking it. Depending on which of caffeine’s methyl groups were originally deuterated, the cytochrome 450 enzymes that kick off its transformation in your liver (ultimately to formaldehyde) would likely balk at the enzymatically more resistant C-D bonds. This will delay the formation of some metabolites, creating a relative preponderance of others.To put this so-called ‘deuterium switch’ into the perspective of a larger business model, consider another devilish operation known in the pharmaceutical world as a ‘chiral switch.’ While often performed in much the same spirit as the deuterium shuffle, the creation of mirrorland molecules is arguably an even more significant, qualitative, and less predictable transformation. A recent radical report documents the creation of a ‘reverse’ DNA polymerase, presumably constructed from mirror image ‘D’ (or right-handed) amino acids. This polymerase has the ability to write mirror image DNA that winds to the left (as opposed to threading like a familiar right-handed screw).The beauty of this emerging “looking-glass” world is that the southpaw polymerase has some unexpected talents—for one, it also writes RNA. Furthermore, researchers like George Church are already on their way to building mirror ribosomes that could be fed this mirror-RNA. Therapeutic mirror RNAs and proteins would have an unparalleled diplomatic immunity in the cell, rendering drugs made from them virtually untouchable by straight enzymes, in many respects upgrading the old Windows 32 cellular OS to 64-bits. Recept concepts. Credit: Luca Turin Plausibility of the vibrational theory of smell More information: Mojca Kržan et al. The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands, PLOS ONE (2016). DOI: 10.1371/journal.pone.0154002 (Phys.org)—The market value for deuterated drugs has recently been estimated at over a billion dollars. Such drugs are simply molecules in which one or more hydrogen atoms are replaced with deuterium. While these kinds of manipulations are known to work wonders as far as breathing new life into aging patents, the overall therapeutic value of this medical manna can be contentious. A recent paper published in PLoS ONE seeks to explain the ‘quantum nature of drug-receptor interactions’ under deuteration using a combined experimental and computational approach. Although a tall order, a more comprehensive and predictive theory of receptor interactions is sorely needed. Perhaps a theory in which the molecular character of drug effects are written less into the receptor and more into the drug itself. © 2016 Phys.org Journal information: PLoS ONE This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Director Kunal Kohli’s acting debut Phir Se is yet to get its release date as the filmmaker is not getting a suitable week for it. The Hum Tum director, who is making his foray into acting opposite TV star Jennifer Winget, said he is looking for a good date. “#PhirSe release date being worked. Next few months packed, looking for a good date, once locked music will follow accordingly,” Kunal posted on Twitter.Phir Se, co-directed by Kunal and debut filmmaker Ajay Bhuyan, is said to be based on a separated couple living in London and they are trying to come to terms with the consequences of their split. The trailer of the film released on April 7, 2015. Phir Se was earlier scheduled to hit theatres in May. The film faced legal trouble when writer Jyoti Kapoor filed a suit against the director for copyright infringement.
Kolkata: The export of jute products and its diversified items has gone up by 24 percent in the last five years, said Union minister for Textile Smriti Zubin Irani.She was addressing a gathering after formally inaugurating the “Artisan Speak and Jute Expo” at the recently restored heritage currency building in the city. It is an outreach initiative of the Union ministry, which will be held here from January 7-10. “We have seen a growth of 24 percent in exports of jute products and diversified products in the last five years. Today we also celebrate the legacy of jute in the country,” Irani said. Also Read – Rain batters Kolkata, cripples normal lifeIt may be mentioned here that delegates from around 14 nations and over 70 buyers are participating in the four-day programme. The Textile industry is the second largest employment sector in India, following the agriculture sector. The sector comprises various fields like cotton, jute, silk, wool, man-made fibres, powerlooms and handicrafts. The event mainly aims at promoting Indian handlooms, handicrafts, silk and jute and providing a platform for marketing and business linkages with both international and domestic buyers. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedThe organisers believe that it will open new opportunities for artisans to exhibit their products. The theme pavilion has an impressive display of handloom products developed by the weavers, along with live demonstrations of exclusive weaves. One of the main objectives of the programme is to create awareness about the textile industry by inviting international buyers, agents and other marketing organizations, apart from establishing Business to Business (B2B) connects. This also gives a platform for viable marketing to improve exports and domestic presence. Secretary of Ministry of Textiles Raghvendra Singh, who was also present in the programme, said the ministry has been trying to find ways and means to enhance the income of weavers and also to connect them with garment manufacturers to increase their margins. The ministry is also supporting weavers and craftsmen in 40 districts of India, Singh added. The event will also showcase textile expositions by many renowned fashion designers from India and NIFT. The expositions will promote Indian jute, silk, handloom and handicrafts. The visitors can choose from a mix of handloom, handicraft, silk and jute products and learn about GI tagging of Baluchari, the pride of the Bengal heritage in the iconic old currency building.
New problem discovered with 737 Max jet, IATA urges further pilot training With file from The Associated Press Tags: Boeing 737 MAX, Federal Aviation Administration, IATA Share MONTREAL — A new computer problem has been found in the troubled Boeing 737 Max that will further delay the plane’s return to flying after two deadly crashes, according to two people familiar with the matter.The latest flaw in the plane’s computer system was discovered by Federal Aviation Administration pilots who were testing an update to critical software in a flight simulator last week at a Boeing facility near Seattle, the people said.Boeing did not immediately respond to a request for comment.One of the people familiar with the discovery said it would add one to three months to the timetable for returning the Max to flight. Both spoke on condition of anonymity because the development has not been made public.In response, IATA, which represents hundreds of airlines, pushed again for additional training on the 737. After holding a meeting in Montreal between airlines and regulators, Alexandre de Juniac, head of IATA, said Thursday in a prepared statement that the aviation industry cannot operate effectively without co-ordination between aircraft operators and regulators.More news: Sunwing to further boost Mazatlán service with new flights from OttawaIf additional training is required, including the possible introduction of simulators for the Max, it could come at a tremendous cost to Boeing.Earlier this month Chesley ‘Sully’ Sullenberger, who landed a crippled airliner safely on the Hudson River in 2009, told the House aviation subcommittee that Max pilots should train for emergencies related to flight-control software in simulators – not just on computers, as Boeing proposes. Several others who testified also criticized Boeing’s pilot training for the aircraft, with some saying that Boeing’s zeal to minimize pilot-training costs for airlines buying the 737 Max jet contributed to design errors and inadequate training.Boeing Co.’s 737 Max fleet has been grounded worldwide after crashes in Indonesia and Ethiopia killed 346 people.Shares of Boeing fell 2.6% before the market open. By: The Associated Press Thursday, June 27, 2019 << Previous PostNext Post >>